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Profound decrease of in vivo formation of thromboxane during oestrogen therapy

P Henriksson1, R Stege, K Gréen

  • 1Department of Medicine, Södertälje Hospital, Sweden.

European Journal of Clinical Investigation
|December 1, 1996
PubMed
Summary
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Parenteral estrogen therapy significantly reduces in vivo thromboxane formation by about 40% in men with prostate cancer. This estrogen effect on thromboxane and prostacyclin balance may benefit cardiovascular health.

Area of Science:

  • Endocrinology
  • Cardiovascular Physiology
  • Metabolomics

Background:

  • Estrogen's influence on platelet activity and eicosanoids (thromboxane, prostacyclin) is debated.
  • Previous studies relied on ex vivo methods with potential artifacts.
  • In vivo assessment of eicosanoid formation is crucial for accurate understanding.

Purpose of the Study:

  • To investigate the in vivo effects of estrogen therapy on thromboxane and prostacyclin formation in men.
  • To compare estrogen therapy with surgical castration in modulating these vasoactive eicosanoids.

Main Methods:

  • Analysis of urinary metabolites 2,3-dinor-thromboxane B2 and 2,3-dinor-6-keto-PGF1 alpha using gas chromatography/mass spectrometry.
  • Study included 10 male prostate cancer patients undergoing parenteral estrogen therapy or orchidectomy.

Related Experiment Videos

  • Utilized tetradeuterated internal standards for precise quantification.

    • Main Results:

    • Parenteral estrogen therapy decreased in vivo thromboxane formation by approximately 40%.
    • Surgical castration led to a doubling of thromboxane formation.
    • The prostacyclin to thromboxane ratio increased by approximately 50% during estrogen therapy.

    Conclusions:

    • Estrogen significantly reduces in vivo thromboxane formation and increases the prostacyclin/thromboxane ratio.
    • These findings suggest potential cardiovascular benefits of estrogen therapy.
    • Increased thromboxane formation post-castration highlights the influence of androgens and sex hormones on this system.