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Triglyceride expression

S Krishnaswami1, G Joseph, S T Chandy

  • 1Department of Cardiology, Christian Medical College Hospital, Vellore, Tamilnadu, India.

International Journal of Cardiology
|December 6, 1996
PubMed
Summary
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Triglycerides play a significant role in coronary artery disease (CAD) development, especially in older adults. This study found triglycerides were more strongly associated with CAD in patients over 51, unlike cholesterol, which was more linked in younger individuals.

Area of Science:

  • Cardiology
  • Epidemiology
  • Lipid Metabolism

Background:

  • Epidemiologic reports highlight the role of triglycerides in coronary artery disease (CAD).
  • Understanding lipid profiles' association with CAD across different age groups is crucial for risk stratification.

Purpose of the Study:

  • To assess the role of triglycerides in coronary artery disease (CAD) across various age groups.
  • To compare the association of different lipid fractions (cholesterol, triglycerides, HDL, LDL) with CAD in younger versus older patients.

Main Methods:

  • Cross-sectional data analysis of 1726 patients (1119 with CAD, 607 normal coronaries) presenting with chest pain.
  • Logistic regression analysis using mean values of lipid profiles and BMI from normal subjects as demarcation lines.
  • Stratification of male patients into age groups: <40, 41-50, 51-60, >61 years; females: <50, >51 years.

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Main Results:

  • Total cholesterol showed higher odds ratios for CAD in younger age groups.
  • Triglycerides demonstrated consistently higher odds ratios for CAD in both males and females over 51 years.
  • Age appears to modify the relative importance of lipid fractions in the development of atherosclerotic plaque.

Conclusions:

  • Triglycerides may be equally or more important than cholesterol in the development of CAD in older individuals (>51 years).
  • Cholesterol may play a more significant role in CAD development among younger populations.
  • Metabolic handling of lipid fractions might differ with age, influencing their impact on atherosclerosis.