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Related Experiment Videos

Pulmonary abnormalities and PET data analysis: a retrospective study

V J Lowe1, F G Duhaylongsod, E F Patz

  • 1Division of Nuclear Medicine, PET Imaging Facility, St Louis University Health Sciences Center, Mo 63110-0250, USA.

Radiology
|February 1, 1997
PubMed
Summary
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Calculating the standard uptake ratio (SUR) for 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) positron emission tomography (PET) using average pixel values improves diagnostic accuracy for pulmonary abnormalities. Different denominators yield equivalent results.

Area of Science:

  • Nuclear Medicine
  • Radiology
  • Oncology

Background:

  • Indeterminate focal pulmonary abnormalities require accurate diagnostic methods.
  • 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) positron emission tomography (PET) is utilized for evaluating these lesions.
  • Standard Uptake Ratio (SUR) is a key metric derived from FDG PET scans.

Purpose of the Study:

  • To evaluate different methods for calculating the Standard Uptake Ratio (SUR) in FDG PET scans.
  • To determine the optimal method for calculating SUR in patients with indeterminate focal pulmonary abnormalities.
  • To compare the diagnostic performance of various SUR calculation techniques.

Main Methods:

  • 197 adult patients with indeterminate pulmonary abnormalities underwent FDG PET imaging.

Related Experiment Videos

  • SUR was calculated using average or maximum pixel values in the numerator.
  • Denominators for SUR calculation included weight, lean body mass, or body surface area.
  • Definitive diagnoses were established via tissue biopsy or 2-year follow-up.

    • Main Results:

    • 120 malignant and 77 benign lesions were identified.
    • Receiver operating characteristic (ROC) curve areas were significantly larger when using average pixel values compared to maximum pixel values for SUR calculation (P <= .05).
    • No statistically significant difference in ROC curve areas was observed between weight, lean body mass, and body surface area as denominators for SUR calculation.

    Conclusions:

    • Standard Uptake Ratio (SUR) calculation using average pixel values significantly enhances ROC curve areas compared to maximum pixel values.
    • Weight, lean body mass, and body surface area are equivalent denominators for SUR calculation in terms of accuracy for this patient group.
    • The findings support the use of average pixel values in SUR calculation for improved diagnostic performance in indeterminate pulmonary abnormalities.