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Related Experiment Videos

Proteases in Fas-mediated apoptosis

B Zhivotovsky1, D H Burgess, J Schlegel

  • 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Journal of Cellular Biochemistry
|January 1, 1997
PubMed
Summary

Cysteine proteases are involved in programmed cell death (apoptosis). Researchers are identifying key proteases that signal or execute apoptosis, particularly in Fas-mediated cell death.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • A unique family of cysteine proteases participates in the complex process of apoptosis.
  • Mammalian genes encoding components of this apoptotic pathway have been identified.
  • The specific roles of individual proteases as apoptotic signals or effectors remain largely undetermined.

Purpose of the Study:

  • To review current research on the involvement of proteases in apoptosis.
  • To clarify the function of specific proteases in Fas-mediated apoptosis.

Main Methods:

  • Literature review of studies on cysteine proteases and apoptosis.
  • Analysis of gene cloning data for mammalian apoptotic components.
  • Focus on research related to Fas-mediated apoptotic pathways.

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Main Results:

  • Evidence supports the involvement of cysteine proteases in apoptosis.
  • Several mammalian genes related to this process have been cloned.
  • The precise signaling or effector roles of these proteases are still under investigation.

Conclusions:

  • Cysteine proteases are integral to the apoptotic process.
  • Further research is needed to elucidate the specific functions of proteases in Fas-mediated apoptosis.