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Proteases in Fas-mediated apoptosis
B Zhivotovsky1, D H Burgess, J Schlegel
1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Abstract:
Involvement of a unique family of cysteine proteases in the multistep apoptotic process has been documented. Cloning of several mammalian genes identifies some components of this cellular response. However, it is currently unclear which protease plays a role as a signal and/or effector of apoptosis. We summarize contributions to the data concerning proteases in Fas-mediated apoptosis.
Insights
Cysteine proteases are involved in programmed cell death (apoptosis). Researchers are identifying key proteases that signal or execute apoptosis, particularly in Fas-mediated cell death.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- A unique family of cysteine proteases participates in the complex process of apoptosis.
- Mammalian genes encoding components of this apoptotic pathway have been identified.
- The specific roles of individual proteases as apoptotic signals or effectors remain largely undetermined.
Purpose of the Study:
- To review current research on the involvement of proteases in apoptosis.
- To clarify the function of specific proteases in Fas-mediated apoptosis.
Main Methods:
- Literature review of studies on cysteine proteases and apoptosis.
- Analysis of gene cloning data for mammalian apoptotic components.
- Focus on research related to Fas-mediated apoptotic pathways.
Main Results:
- Evidence supports the involvement of cysteine proteases in apoptosis.
- Several mammalian genes related to this process have been cloned.
- The precise signaling or effector roles of these proteases are still under investigation.
Conclusions:
- Cysteine proteases are integral to the apoptotic process.
- Further research is needed to elucidate the specific functions of proteases in Fas-mediated apoptosis.