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The SWISS-PROT protein sequence data bank and its supplement TrEMBL
1Department of Medical Biochemistry, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland. bairoch@cmu.unige.ch
Nucleic Acids Research
|January 1, 1997
Summary
SWISS-PROT is a comprehensive protein sequence database offering detailed annotations and integration. A new supplement, TrEMBL, expands coverage by including computer-annotated entries from nucleotide sequence data.
Area of Science:
- Bioinformatics
- Molecular Biology
- Genomics
Background:
- SWISS-PROT is a high-quality, curated protein sequence database.
- It provides extensive annotations including protein function, domain structure, and post-translational modifications.
- Database integration and minimal redundancy are key features.
Purpose of the Study:
- To describe recent developments and expansions of the SWISS-PROT database.
- To introduce TrEMBL, a new computer-annotated supplement.
- To enhance the scope and utility of protein sequence information.
Main Methods:
- Continued curation and expansion of model organism coverage.
- Integration with additional external databases.
- Development of TrEMBL through automated translation of coding sequences (CDS) from the EMBL nucleotide sequence database.
Main Results:
- Increased number and scope of model organisms represented.
- Establishment of cross-references to two new databases.
- Creation and population of TrEMBL with computer-annotated protein sequences.
- Exclusion of already SWISS-PROT-annotated CDS from TrEMBL.
Conclusions:
- SWISS-PROT continues to enhance its value through expanded data and integration.
- TrEMBL significantly increases the breadth of available protein sequence information.
- The combined resources offer a more comprehensive view of protein data.