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The uRNA database

C Zwieb1

  • 1Department of Molecular Biology, The University of Texas Health Science Center at Tyler, Highway 271 N, PO Box 2003, Tyler, TX 75710, USA. zwieb@jason.uthct.edu

Nucleic Acids Research
|January 1, 1997
PubMed
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The updated uRNADB now includes aligned and annotated sequences for U7, U8, U11, U12, U14, U18, U48, and U49 small nuclear RNAs (snRNAs). This release significantly expands the database for comparative RNA studies.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • Small nuclear RNAs (snRNAs) are crucial non-coding RNAs involved in various cellular processes.
  • Databases that provide aligned and annotated RNA sequences are essential for comparative genomics and evolutionary studies.
  • The uRNADB serves as a valuable resource for researchers studying U RNA families.

Purpose of the Study:

  • To update and expand the uRNADB with new U RNA sequences.
  • To provide aligned, annotated, and phylogenetically ordered sequences for newly included U RNAs.
  • To integrate these new sequences with existing U1-U6 snRNAs for comprehensive analysis.

Main Methods:

  • Curating and collecting new U RNA sequences (U7, U8, U11, U12, U14, U18, U48, U49).

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  • Aligning the new sequences with established U1-U6 snRNA sequences.
  • Annotating the sequences to provide functional and structural information.
  • Phylogenetic ordering of the aligned sequences to infer evolutionary relationships.

    • Main Results:

    • Addition of 14 U7, 2 U8, 3 U11, 2 U12, 11 U14, and single sequences for U18, U48, and U49 RNAs.
    • A total of 34 new sequences were incorporated into the database.
    • All new sequences were aligned and annotated alongside previously compiled U1, U2, U3, U4, U5, and U6 snRNAs.

    Conclusions:

    • The expanded uRNADB offers a more comprehensive resource for studying U RNA evolution and function.
    • Researchers can now perform more robust comparative analyses across a wider range of U RNA families.
    • This update facilitates deeper insights into the roles of snRNAs in different organisms.