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The RNA modification database

P F Crain1, J A McCloskey

  • 1Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.

Nucleic Acids Research
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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This RNA modification database offers a comprehensive catalog of post-transcriptionally modified nucleosides from all RNAs. It details each nucleoside

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • Post-transcriptional modifications are crucial for RNA function.
  • A centralized resource for modified nucleosides is essential for researchers.
  • Previous databases existed but required updating.

Purpose of the Study:

  • To provide an updated and comprehensive online database of all known post-transcriptionally modified nucleosides.
  • To consolidate information on nucleoside occurrence, distribution, nomenclature, and chemical properties.
  • To facilitate access to this data via the World Wide Web and anonymous FTP.

Main Methods:

  • Compilation of data from scientific literature, including the initial printed report by Limbach et al. (1994).
  • Inclusion of information on RNA type, phylogenetic distribution, chemical name, Chemical Abstracts registry number, structure, and literature citations.

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  • Data organization for online accessibility.

    • Main Results:

    • A comprehensive listing of post-transcriptionally modified nucleosides is now available.
    • Detailed information for each nucleoside includes its occurrence, distribution, chemical identity, and structural data.
    • The database is accessible online, enhancing research accessibility.

    Conclusions:

    • The updated RNA modification database serves as a vital resource for the scientific community.
    • It facilitates research in RNA biology, biochemistry, and related fields.
    • Easy online access promotes wider use and further research into RNA modifications.