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The Nuclear Receptor Resource Project

E Martinez1, D D Moore, E Keller

  • 1Department of Biochemistry and Molecular Biology, Georgetown University Medical School, 3900 Reservoir Road, NW, Washington, DC 20007, USA.

Nucleic Acids Research
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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The Nuclear Receptor Resource (NRR) expands the Glucocorticoid Receptor Resource (GRR) to include multiple nuclear receptor databases. This integrated platform aims to be a central hub for nuclear receptor research and data sharing.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Bioinformatics

Background:

  • The Glucocorticoid Receptor Resource (GRR) was an established database for glucocorticoid receptor information.
  • Nuclear receptors play critical roles in various physiological processes and disease states.

Purpose of the Study:

  • To expand the GRR into a comprehensive Nuclear Receptor Resource (NRR).
  • To create an integrated platform for accessing diverse nuclear receptor information.
  • To foster a community for discussing published and unpublished research on nuclear receptors.

Main Methods:

  • Integration of multiple specialized databases (Thyroid Hormone Receptor, Androgen Receptor, Mineralocorticoid Receptor, Vitamin D Receptor, Steroid Receptor Associated Proteins) under the NRR umbrella.
  • Centralized access via a project Home Page (http://nrr.georgetown.edu/nrr.html).

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  • Management of individual resources from different servers with integrated file access.

    • Main Results:

    • The NRR now encompasses the original GRR and six additional specialized resources.
    • A unified web portal provides access to all integrated data.
    • The NRR serves as a centralized repository for nuclear receptor information.

    Conclusions:

    • The NRR provides a comprehensive and integrated resource for the nuclear receptor superfamily.
    • The platform facilitates data dissemination and discussion among researchers.
    • Future expansion and enhanced electronic publication systems are planned, encouraging investigator involvement.