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MmtDB: a Metazoa mitochondrial DNA variants database

D Calò1, A De Pascali, D Sasanelli

  • 1Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, 70125 Bari, Italy. areadc13@area.ba.cnr.it

Nucleic Acids Research
|January 1, 1997
PubMed
Summary

MmtDB is a new database for Metazoa mitochondrial DNA variants, prioritizing human data. It collects, annotates, and cross-references genetic variations for research.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Mitochondrial DNA (mtDNA) variants are crucial for understanding Metazoa evolution and diseases.
  • A centralized, specialized database for Metazoa mtDNA variants is needed to facilitate research.

Purpose of the Study:

  • To describe the structure and content of MmtDB, a novel database for Metazoa mitochondrial DNA variants.
  • To establish a comprehensive resource for collecting, annotating, and cross-referencing mtDNA variations.

Main Methods:

  • Data collection from Nucleotide Sequence Databases and other sources.
  • Redundant sequence removal and addition of new sequences.
  • Association of value-added information, including experimental methods, population data, and variation details.

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  • Implementation of internal and external cross-referencing (e.g., EMBL Data Library).

    • Main Results:

    • MmtDB has been established, featuring a specialized collection of Metazoa mtDNA variants.
    • The database includes detailed annotations for each variant, such as analyzed region, tissue, sex, age, and variation events.
    • Internal cross-referencing links entries based on tissual, heteroplasmic, familiar, and aplotypical correlations.

    Conclusions:

    • MmtDB provides a valuable, accessible resource for researchers studying Metazoa mitochondrial DNA.
    • The database structure facilitates efficient data retrieval and analysis of mtDNA variations.
    • MmtDB supports comparative genomics and evolutionary studies of mitochondrial genomes.