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SCOP: a structural classification of proteins database

T J Hubbard1, A G Murzin, S E Brenner

  • 1MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK.

Nucleic Acids Research
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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The Structural Classification of Proteins (SCOP) database classifies protein structures hierarchically. It uniquely distinguishes evolutionary relationships from physical and chemical ones, offering extensive data and web accessibility.

Area of Science:

  • Structural biology
  • Bioinformatics
  • Computational biology

Background:

  • Protein structure classification is crucial for understanding biological function and evolution.
  • Existing databases often focus on evolutionary relationships, potentially conflating them with physical constraints.

Purpose of the Study:

  • To introduce the Structural Classification of Proteins (SCOP) database.
  • To highlight SCOP's unique hierarchical classification system.
  • To detail the resources and accessibility of the SCOP database.

Main Methods:

  • Hierarchical classification of protein structures into family, superfamily, and fold levels.
  • Distinguishing between evolutionary relationships and those derived from protein physics and chemistry.
  • Linking structural data to atomic coordinates, images, and literature.

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Main Results:

  • SCOP provides a comprehensive classification of known protein structures.
  • It uniquely separates evolutionary relationships from structural/physical relationships.
  • The database offers extensive supplementary data including atomic coordinates and literature links.

Conclusions:

  • SCOP serves as a valuable resource for researchers studying protein structure, evolution, and function.
  • Its unique classification approach offers new insights into protein relationships.
  • The database is freely accessible online, promoting widespread use in the scientific community.