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Suspected acute interstitial nephritis induced by piperacillin-tazobactam
M W Pill1, C V O'Neill, M M Chapman
1Department of Pharmacy, New England Medical Center, Boston, MA 02111, USA.
Pharmacotherapy
|January 1, 1997
Summary
Piperacillin-tazobactam can cause acute interstitial nephritis, a kidney injury. Promptly stopping the antibiotic and using steroids resolved the patient's symptoms and restored kidney function.
Area of Science:
- Nephrology
- Pharmacology
- Internal Medicine
Background:
- Acute interstitial nephritis (AIN) is a potential adverse drug reaction.
- Antibiotics are a common cause of AIN.
- Piperacillin-tazobactam is a widely used antibiotic combination.
Observation:
- A 51-year-old woman presented with acute renal dysfunction, rash, pain, fever, and eosinophiluria.
- These symptoms emerged after six days of intravenous piperacillin-tazobactam therapy.
- Renal function tests showed elevated serum creatinine.
Findings:
- Discontinuation of piperacillin-tazobactam led to symptom resolution.
- A 21-day course of prednisone further aided recovery.
- Renal function returned to the patient's baseline levels.
- This case suggests piperacillin-tazobactam as a potential cause of AIN, a previously unreported association.
Implications:
- Clinicians should consider piperacillin-tazobactam as a potential cause of AIN in patients presenting with relevant symptoms.
- Early recognition and drug withdrawal are crucial for managing antibiotic-induced AIN.
- This finding expands the known spectrum of adverse effects associated with piperacillin-tazobactam.