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Related Experiment Videos

Incorrect overdose management advice in the Physicians' Desk Reference

W H Mullen1, I B Anderson, S Y Kim

  • 1School of Pharmacy, University of California, USA. w@wtnx.com

Annals of Emergency Medicine
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

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Physicians

Area of Science:

  • Clinical Toxicology
  • Medical Informatics

Background:

  • Physicians often rely on the Physicians' Desk Reference (PDR) for overdose management guidance.
  • PDR recommendations, though FDA-approved, may be outdated and pose risks.

Purpose of the Study:

  • To evaluate the accuracy and safety of PDR overdose management advice.
  • To compare PDR recommendations with current toxicology reference standards.

Main Methods:

  • Surveyed physicians on their use of the PDR for overdose information.
  • Analyzed PDR entries for 20 leading drugs across high-mortality categories.
  • Compared PDR advice against a consensus from five major toxicology references.

Main Results:

  • 50% of surveyed physicians reported using the PDR for overdose information.

Related Experiment Videos

  • 80% of PDR entries reviewed had at least one deficiency.
  • 65% omitted indicated treatments; 35% recommended ineffective or contraindicated therapies.

    • Conclusions:

    • Significant discrepancies exist between PDR overdose advice and current toxicology consensus.
    • PDR recommendations frequently contain deficiencies, including harmful advice.
    • Relying on PDR for serious poisonings may lead to adverse patient outcomes.