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[Syndromes with neural tube defects: epidemiologic analysis in Spain]
M L Martínez-Frías1, V Félix Rodríguez, F Hernández Ramón
1ECEMC, Facultad de Medicina, Universidad Complutense, Madrid.
Objective:
We present, from an epidemiological perspective, the analysis of syndromes which present neural tube defects (NTD). Although there are many epidemiological studies on NTD all over the world, most of them are on isolated NTD; that is, when the infant only has NTD as the only anomaly.
Patients And Methods:
The methodology is based on the review of hospital records of infants with congenital anomalies. This permitted the analysis of the prevalence.
Results:
The results show that the frequency of syndromes with NTD is 27.5 time higher among stillborn infants than among liveborn infants. Nevertheless, there are not many syndromes in which the NTD are present more or less frequently. In fact, only 1.93% of the total cases with syndromes presented NTD, with the majority (43.4%) with genetic etiology. We also analyze the specific types of syndromes with NTD.