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Influencing factors on ESR bone dosimetry
S Onori1, M Pantaloni, S Baccaro
1Physics Laboratory, Istituto Superiore di Sanità, Rome, Italy.
Summary
Temperature during irradiation impacts the type and number of radiation-induced free radicals in bone. Higher dose rates may slightly decrease radical concentration, affecting bone
Area of Science:
- Biophysics
- Materials Science
- Radiation Chemistry
Background:
- Understanding radiation effects on biological materials like bone is crucial.
- Free radicals generated in bone post-irradiation can affect its properties and stability.
- Non de-proteinized bone is a relevant model for studying these effects.
Purpose of the Study:
- To investigate the influence of irradiation temperature on free-radical yield in bone.
- To determine the effect of dose rate on radiation-induced free radicals in bone.
- To assess the time stability of these radicals under varying conditions.
Main Methods:
- Irradiation of chicken leg bone samples within a specific temperature range (253-293 K).
- Utilizing two distinct radiation sources: Cobalt-60 (60Co) at 0.6 Gy/s and 12 MeV electrons at 6 x 10^6 Gy/s.
- Analysis of radiation-induced free-radical yield and their temporal stability.
Main Results:
- Irradiation temperature significantly influences the type and quantity of free radicals formed in bone.
- Radical concentration appears to exhibit a slight decrease with increasing dose rate.
- The study quantifies these effects for non de-proteinized bone.
Conclusions:
- Temperature is a critical factor controlling free radical generation during bone irradiation.
- Dose rate plays a role in modulating radical concentration, though the effect is less pronounced.
- Findings provide insights into the radiation chemistry of bone and its stability.