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Systemic autoimmunity in LG/J mice

S L Peng1, M P Madaio, J Craft

  • 1Department of Biology, Yale University, New Haven, CT, USA.

Immunology Letters
|November 1, 1996
PubMed
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LG/J mice, previously considered healthy, unexpectedly develop autoantibodies and kidney disease, challenging their use in lupus research. This finding suggests LG/J mice may serve as a valuable model for studying autoimmunity.

Area of Science:

  • Immunology
  • Nephrology
  • Genetics

Background:

  • LG/J mice are traditionally regarded as a healthy control strain in autoimmune research.
  • The MRL murine model of lupus erythematosus heavily relies on the LG/J genetic background.

Purpose of the Study:

  • To investigate humoral and end-organ parameters of autoimmunity in LG/J mice.
  • To assess the suitability of LG/J mice for genetic studies of lupus erythematosus.

Main Methods:

  • Analysis of autoantibodies (antinuclear antibodies, rheumatoid factor) in LG/J mice.
  • Histopathological examination of organs (kidneys, liver, skin) for signs of disease.
  • Comparison with age-matched, identically-housed control mice.

Main Results:

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  • LG/J mice exhibited autoantibodies, including antinuclear antibodies and rheumatoid factor.
  • Renal disease, characterized by glomerulonephritis, interstitial nephritis, and perivasculitis, was observed in LG/J mice.
  • No hepatic or cutaneous disease was detected in LG/J mice.
  • Control mice did not develop autoantibodies or end-organ disease.

Conclusions:

  • LG/J mice spontaneously develop autoimmune phenomena, including autoantibodies and renal disease.
  • The presence of autoimmunity in LG/J mice has significant implications for lupus erythematosus genetic studies.
  • LG/J mice represent a potential model for autoimmunity research.