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Updated: Aug 12, 2026

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
Published on: November 1, 2012
Effects of fatiguing isometric and isotonic exercise on resisted and unresisted reaction time components
Abstract:
Fractionated resisted and unresisted RT for a knee-extension task was assessed on 12 male subjects over a 10-day treatment period. The first 4 days were baseline days and were designed to stabilize all RT values as well as strength measures. For the next 6 days the subjects were alternately administered isometric and isotonic exercise designed to fatigue the quadriceps musculature. Although significant strength decrements were manifested for both isometric exercise (57%) and isotonic exercise (35%), no changes were shown in the unresisted fractionated RT components. Conversely all resisted RT changes were manifested in the muscular component suggesting a peripheral site for neuromuscular fatigue.
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