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Vitamin E modifies neither fructosamine nor HbA1c levels in poorly controlled diabetes
F J Gómez-Pérez1, V E Valles-Sanchez, J C López-Alvarenga
1Department of Diabetes and Lipid Metabolism, Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F.
Objective:
To examine the effects of vitamin E on total serum protein glycation (fructosamine), hemoglobin glycation (HbA1c), and serum levels of glucose, total cholesterol, triglycerides, LDL-C, HDL-C, apolipoprotein A1 and apolipoprotein B.
Material And Methods:
Sixty poorly controlled diabetic patients were randomly assigned to receive either 1200 mg/day of vitamin E or identical placebo capsules during a two month period following a double blind cross-over design with a four week wash-out period between regimens.
Results:
Seven patients were excluded from the study because of reasons not related to the medication. In the remaining 53 patients, the levels of serum glucose, fructosamine, HbA1c, total cholesterol, HDL-C, LDL-C, Apo A1 and Apo B did not vary significantly with vitamin E as compared with placebo.
Conclusions:
No significant effects of vitamin E on any of the parameters evaluated were observed in poorly controlled diabetic patients.