Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive function in younger type II diabetes

J Dey1, A Misra, N G Desai

  • 1Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Diabetes Care
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Split cord malformation type 1.5: a rare entity.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2025
Same author

Hydrocephalus in snake bite: a rare manifestation with review of literature.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2025
Same author

Unusual spinal injury in a child caused by a wooden foreign body.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2024
Same author

Pulsatile giant sacrococcygeal teratoma appearing like 2nd head.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2024
Same author

Cerebral Myiasis Secondary to Burr Hole Evacuation: A Rare Illustrative Case Report.

Asian journal of neurosurgery·2023
Same author

Thoracic bony human tail in a newborn baby: a rare case and review of literature.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2023
Same journal

A Secular Increase in the Incidence of Islet Autoimmunity Among Colorado Children With Moderate-Risk HLA Genotypes.

Diabetes care·2026
Same journal

Clinical and Biochemical Recovery From Immune Checkpoint Inhibitor-Induced Diabetes With Seroconversion of GAD Antibodies.

Diabetes care·2026
Same journal

State Insulin Out-of-Pocket Cap Policies and Estimated Eligible Populations in the United States, 2019-2026.

Diabetes care·2026
Same journal

Genetic Determinants of Macronutrient Intake Are Associated With Specific Food Intake in Youth: A Cohort Study Across Childhood and Adolescence.

Diabetes care·2026
Same journal

A Novel Electronic Medical Record Search Method to Identify Patients With Ketosis-Prone Diabetes: Implications for Discovery of Atypical Diabetes.

Diabetes care·2026
Same journal

Real-Time Continuous Glucose Monitoring Among People With Type 2 Diabetes and End-Stage Kidney Failure Undergoing Maintenance Hemodialysis: A Randomized Clinical Trial.

Diabetes care·2026
See all related articles

Type 2 diabetes can impact cognitive function, even in younger adults. This study found that patients with diabetes showed delayed brain responses and impairments in attention, repetition, and memory compared to controls.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychology

Background:

  • Diabetes mellitus, particularly non-insulin-dependent diabetes mellitus (NIDDM), is a systemic disease with potential for neurological complications.
  • Central nervous system (CNS) involvement is increasingly recognized but often overlooked in younger NIDDM patients.

Purpose of the Study:

  • To investigate potential CNS complications in relatively young NIDDM patients (<55 years) through a comprehensive neuropsychological evaluation.
  • To compare cognitive function and neurophysiological markers between NIDDM patients and age-matched healthy controls.

Main Methods:

  • A cross-sectional study involving 28 NIDDM patients (diabetes duration 5-18 years) and 28 demographically similar controls.
  • Neuropsychological assessments included the Mini-Mental Status Examination (MMSE), Neurobehavioral Cognitive Status Examination (NCSE), and P300 event-related potentials (ERPs).

Related Experiment Videos

  • Patients were screened for glycemic control and absence of hypoglycemia.

    • Main Results:

    • Diabetic patients exhibited significantly delayed P300 latencies (mean 349.5 ms vs. 312.9 ms in controls, P < 0.001).
    • Compared to controls, NIDDM patients showed higher rates of impairment in NCSE tests of attention (P < 0.01), repetition (P < 0.05), and memory (P < 0.05).
    • No significant differences were found in MMSE scores or specific NCSE domains (comprehension, naming, construction, calculation).

    Conclusions:

    • Central nervous system impairment, characterized by subtle deficits in attention, memory, and processing speed, is a potential complication of long-standing NIDDM.
    • These cognitive impairments can occur even in younger NIDDM individuals and warrant clinical recognition.
    • Delayed P300 latencies may serve as a neurophysiological marker for CNS involvement in diabetes.