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2-hydroxyethyl methacrylate-terminated polyurethane/polyurethane interpenetrating polymer networks
1Department of Chemical Engineering, National Taiwan Institute of Technology, Taipei.
Journal of Biomedical Materials Research
|February 1, 1997
Summary
Interpenetrating polymer networks (IPNs) of polyurethane (PU) and 2-hydroxyethyl methacrylate-terminated polyurethane (HPU) were synthesized. Optimized HPU content (25 wt%) minimized platelet adhesion on these biocompatible membranes.
Area of Science:
- Polymer Science
- Biomaterials Science
Background:
- Interpenetrating polymer networks (IPNs) offer tunable properties for advanced applications.
- Polyurethane (PU) and its derivatives are widely explored for biomedical uses.
Purpose of the Study:
- To synthesize and characterize novel IPNs composed of PU and HPU.
- To investigate the relationship between HPU content and the mechanical, surface, and blood compatibility properties of the IPNs.
Main Methods:
- Solution polymerization was used to create PU/HPU IPN membranes.
- Dynamic mechanical analysis, surface tension measurements, and ESCA were employed for characterization.
- Dynamic thrombosis testing assessed platelet adhesion (RIPA).
Main Results:
- The IPNs exhibited good compatibility between PU and HPU constituents.
- Optimal tensile strength and minimum platelet adhesion were achieved at approximately 25 wt% HPU.
- Surface analysis revealed that higher HPU content increased soft segment migration, correlating with reduced platelet adhesion.
Conclusions:
- The developed PU/HPU IPNs demonstrate promising hemocompatibility.
- Surface composition, particularly the soft segment to hard segment ratio, significantly influences blood-contact performance.
- The study identifies an optimal formulation for enhanced biocompatibility in IPN membranes.