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Related Experiment Videos

Experimental peri-implant tissue breakdown around hydroxyapatite-coated implants

O Hanisch1, C A Cortella, M M Boskovic

  • 1Center for Prosthodonotics and Implant Dentistry, Loma Linda University, CA, USA.

Journal of Periodontology
|January 1, 1997
PubMed
Summary

Experimental plaque accumulation around hydroxyapatite-coated implants in non-human primates led to peri-implant tissue breakdown. The study highlights a preclinical model for peri-implantitis, crucial for developing new treatments.

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Area of Science:

  • Dental Implantology
  • Periodontology
  • Microbiology

Background:

  • Peri-implant tissue breakdown is a significant concern following dental implant placement.
  • Hydroxyapatite (HA)-coated implants are widely used, but understanding their response to plaque accumulation is critical.

Purpose of the Study:

  • To investigate experimental peri-implant tissue breakdown around HA-coated titanium implants in a non-human primate model.
  • To analyze the associated submucosal microbiota changes during plaque accumulation and resolution.

Main Methods:

  • Thirty-two HA-coated implants were placed in Macaca mulatta monkeys.
  • Plaque accumulation was induced using cotton ligatures around healing abutments.
  • Clinical, radiographic, and submucosal microbial samples were collected at various time points.

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Main Results:

  • Plaque accumulation significantly increased modified plaque index, gingival index, and bleeding on probing.
  • Progressive probing depth and clinical attachment level increases were observed.
  • Submucosal microbiota shifted to include Gram-negative anaerobic rods, including Porphyromonas gingivalis, resembling human peri-implantitis.

Conclusions:

  • Ligature-induced plaque accumulation is a precursor to peri-implant tissue breakdown around HA-coated implants.
  • The observed microbiota changes mimic those found in human peri-implantitis and destructive periodontal disease.
  • This preclinical model is valuable for studying interventions for peri-implantitis and bone regeneration.