Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptosis in steroidogenic cells: structure-function analysis

A Amsterdam1, A Dantes, N Selvaraj

  • 1Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Steroids
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thyrotoxicosis With Medullary Thyroid Carcinoma: A Rare Endocrine Diagnostic Challenge.

Cureus·2025
Same author

Production of high performance AA7150-1% SiC nanocomposite by novel fabrication process of ultrasonication assisted stir casting.

Ultrasonics sonochemistry·2019
Same author

The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.

Leukemia·2016
Same author

Anti-inflammatory and proapoptotic effects of umbelliferone in colon carcinogenesis.

Human & experimental toxicology·2015
Same author

Pre-hypertension: Is it an inflammatory state?

Clinica chimica acta; international journal of clinical chemistry·2015
Same author

An efficient in vitro system for somatic embryogenesis and podophyllotoxin production in Podophyllum hexandrum Royle.

Protoplasma·2014
Same journal

Steroidal alkaloids as multi-target therapeutics for the treatment of endometriosis.

Steroids·2026
Same journal

Emerging trends for therapeutic valuation of Cyclopamine: Structural features, mechanism of action, and formulation strategies.

Steroids·2026
Same journal

The antiproliferative and antimigratory properties of the 3-biotin-B-norcholesteryl benzimidazole derivative in MCF-7 cells are mediated through G1 phase arrest and apoptosis.

Steroids·2026
Same journal

Development and validation of an LC-MS method for quantification of sex steroid hormones in skeletal muscle.

Steroids·2026
Same journal

Circulating 4β-hydroxycholesterol as a biomarker of CYP3A4 activity: beyond drug development.

Steroids·2026
Same journal

Impact of glycosylation position on flavonoid isomers' inhibition of breast cancer-associated enzyme CYP1B1.

Steroids·2026
See all related articles

Granulosa cell apoptosis is regulated by various factors, influencing ovarian function and pregnancy. Even during cell death, steroid hormone production can continue if the steroidogenic apparatus remains intact.

Area of Science:

  • Reproductive Biology
  • Cell Biology
  • Endocrinology

Background:

  • Granulosa cells produce progesterone and estradiol, crucial for ovarian cyclicity.
  • Ovarian apoptosis regulates follicle numbers, impacting fertility and pregnancy.
  • Granulosa cell apoptosis is influenced by endocrine, paracrine, and autocrine signals.

Purpose of the Study:

  • To investigate the maintenance of steroidogenesis during granulosa cell apoptosis.
  • To understand the cellular mechanisms enabling steroid hormone production during programmed cell death.

Main Methods:

  • Cellular and molecular biology techniques to study granulosa cell apoptosis.
  • Analysis of steroidogenic apparatus integrity and organelle localization during apoptosis.
  • Investigation of cytoskeletal reorganization and proteasome migration in apoptotic cells.

Related Experiment Videos

Main Results:

  • Steroidogenesis can be sustained in early apoptosis if the steroidogenic apparatus is intact.
  • Compartmentalization of steroidogenic organelles and proteasome migration to blebs facilitate continued steroid production.
  • Actin cytoskeleton reorganization may protect steroidogenic activity from proteolytic degradation.

Conclusions:

  • Granulosa cells possess mechanisms to maintain steroid hormone production during apoptosis.
  • Cellular reorganization allows for continued progesterone secretion, essential for pregnancy maintenance, even during cell death.
  • The integrity of the steroidogenic apparatus is key to sustained steroidogenesis in apoptotic cells.