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Adoptive immunotherapy for Epstein-Barr virus-related lymphoma
C A Smith1, C Y Ng, S K Loftin
1Department of Hematology and Oncology, St. Jude Childrens' Research Hospital, Memphis, TN. 38105, USA.
Leukemia & Lymphoma
|October 1, 1996
Abstract:
Epstein-Barr virus (EBV) causes opportunistic B cell lymphomas in patients whose cellular immunity is compromised. We have been investigating whether infusions of donor-derived, EBV-specific cytotoxic T cells can prevent and/or treat EBV-related lymphoproliferative disease in children receiving T cell-depleted bone marrow from HLA-matched, unrelated or HLA-mismatched, related donors. In this review, we discuss the rationale for this therapeutic approach, describe our experiences with the regimen thus far, and consider some future directions in immunotherapy.