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Plasminogen activation by invasive human pathogens

M D Boyle1, R Lottenberg

  • 1Department of Microbiology, Medical College of Ohio, Toledo 43699-0008, USA. Boyle@opus.mco.edu

Thrombosis and Haemostasis
|January 1, 1997
PubMed
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Invasive pathogens hijack the human plasmin system using plasmin(ogen) receptors and activators. This allows pathogens to evade host defenses and potentially cross tissue barriers.

Area of Science:

  • Microbiology
  • Biochemistry
  • Pathogenesis

Background:

  • The human plasmin system is crucial for regulating blood clots.
  • Invasive pathogens can interact with the human plasmin system.
  • Understanding these interactions is key to combating infections.

Purpose of the Study:

  • To review how invasive pathogens interact with the human plasmin(ogen) system.
  • To explore mechanisms pathogens use to bind plasmin.
  • To discuss the role of these interactions in tissue invasion.

Main Methods:

  • Literature review of studies on pathogen-plasminogen interactions.
  • Analysis of mechanisms for plasmin acquisition by pathogens.
  • Discussion of evidence for pathogen-mediated plasmin binding.

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Main Results:

  • Pathogens utilize plasmin(ogen) receptors and/or produce plasminogen activators.
  • Multiple mechanisms exist for pathogens to acquire surface-bound plasmin.
  • This surface-bound plasmin is often resistant to host serpin regulation.

Conclusions:

  • Pathogen interaction with the plasmin system is a significant virulence factor.
  • Surface-bound, unregulated plasmin aids pathogens in crossing host tissue barriers.
  • Targeting these pathogen-host interactions could offer new therapeutic strategies.