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Related Experiment Videos

Quality assessment of a prenatal screening program

G J Knight1

  • 1Foundation for Blood Research, Scarborough, ME 04074, USA.

Early Human Development
|December 30, 1996
PubMed
Summary
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Epidemiologic monitoring uses screened population data for quality control in prenatal screening. This method helps detect issues with assays and data adjustments, improving screening accuracy for neural tube defects and Down's syndrome.

Area of Science:

  • Prenatal screening
  • Clinical laboratory science
  • Quality control in diagnostics

Background:

  • Epidemiologic monitoring utilizes screened population data as a quality control measure.
  • Commonly, laboratories track positive test result percentages for open neural tube defect (ONTD) and Down's syndrome screening.
  • These percentages are susceptible to assay inaccuracies, imprecise data, and assay drift.

Purpose of the Study:

  • To highlight the utility of epidemiologic monitoring in prenatal screening.
  • To explain the application of monitoring multiples of the median (MoM) in ONTD and Down's syndrome screening.
  • To demonstrate how monitoring median MoM identifies issues with adjustment factors.

Main Methods:

  • Monitoring the percentage of screen-positive results.

Related Experiment Videos

  • Calculating median MoM for each assay in multi-assay screening protocols.
  • Analyzing patient MoM values to assess assay performance and adjustment factors.

    • Main Results:

    • Epidemiologic monitoring identifies problems not apparent with traditional quality control.
    • Monitoring median MoM is crucial for simultaneous assay monitoring in Down's syndrome screening.
    • This method can detect inappropriate adjustment factors, such as those for maternal weight.

    Conclusions:

    • Epidemiologic monitoring is an effective quality control tool in prenatal screening.
    • It enhances the reliability of ONTD and Down's syndrome screening by detecting assay and data issues.
    • This approach improves the overall accuracy and quality of diagnostic testing.