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Related Experiment Videos

Ketamine anesthesia in electroconvulsive therapy

K G Rasmussen1, M R Jarvis, C F Zorumski

  • 1Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.

Convulsive Therapy
|December 1, 1996
PubMed
Summary
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Ketamine anesthesia during electroconvulsive therapy (ECT) did not prolong seizures and caused elevated blood pressure. While generally well-tolerated psychologically, ketamine is unlikely to be a superior anesthetic for ECT seizure enhancement.

Area of Science:

  • Neuroscience
  • Anesthesiology
  • Psychiatry

Background:

  • Ketamine anesthesia in electroconvulsive therapy (ECT) is limited by blood pressure effects and psychological concerns.
  • Ketamine is considered an alternative to methohexital for potentially prolonging seizure duration in ECT.
  • Limited data exists on ketamine's efficacy in prolonging seizures during ECT.

Purpose of the Study:

  • To evaluate the effect of ketamine anesthesia on seizure length during ECT.
  • To assess blood pressure changes and psychological reactions in patients receiving ketamine for ECT.
  • To compare ketamine's impact on ECT seizures with methohexital.

Main Methods:

  • A case series of 10 patients undergoing ECT with ketamine anesthesia.
  • Monitoring of blood pressure and seizure duration.

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  • Assessment of psychological adverse reactions.

    • Main Results:

    • Ketamine anesthesia resulted in elevated blood pressure compared to methohexital.
    • Seizure lengths were nonsignificantly decreased with ketamine.
    • No adverse psychological reactions were observed; ketamine was generally well tolerated.

    Conclusions:

    • Ketamine anesthesia, at the doses used, is unlikely to prolong seizures in ECT.
    • Ketamine may warrant further investigation for ECT due to theoretical considerations.
    • Ketamine's use in ECT requires careful consideration of its hemodynamic effects.