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[Antibiotic resistance in Salmonella enterica: an increasing problem]
J C Galán1, M Varea, F J Castillo
1Servicio de Microbiología, Hospital Clínico Universitario Lozano Blesa, Zaragoza.
Enfermedades Infecciosas Y Microbiologia Clinica
|November 1, 1996
Summary
Salmonella enterica serotype frequencies and antimicrobial resistance evolved between 1990-1994. Typhimurium, a resistant serotype, increased, limiting treatment options to cotrimoxazole and fluoroquinolones.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Context:
- Salmonella enterica is a significant cause of bacterial gastroenteritis.
- Antimicrobial resistance in S. enterica poses a growing public health concern.
- Understanding serotype prevalence and resistance patterns is crucial for effective treatment strategies.
Purpose:
- To analyze the temporal trends in S. enterica serotype isolation.
- To assess the evolving antimicrobial resistance patterns of S. enterica serotypes.
- To identify shifts in the frequency of multidrug-resistant strains.
Summary:
- Enteritidis was the most common serotype (62.9%) but decreased from 76.2% to 39.8% between 1990 and 1994.
- Typhimurium exhibited high resistance to ampicillin, streptomycin, chloramphenicol, and tetracycline.
- Multidrug-resistant strains increased from 9.7% to 22.9%, predominantly in serogroup B.
Impact:
- The rise of multidrug-resistant Typhimurium necessitates careful selection of antimicrobial agents.
- Cotrimoxazole remains a viable option for children, while fluoroquinolones are recommended for adults.
- Third-generation cephalosporins show promise as an alternative treatment for therapeutic failures.