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[Time organization of blood coagulation in patients with rheumatic heart disease involving circulation insufficiency]
R M Zaslavskaia1, S I Logvinenko, M M Teiblium
1Russian Academy of Postdiploma Education, Moscow.
Insights
Chronotherapy with heparin and curantyl can correct disordered blood coagulation in patients with rheumatic heart disease and circulatory insufficiency. This treatment improves the time organization of hemostasis in decompensated heart disease.
Area of Science:
- Cardiology
- Hematology
- Pharmacology
Background:
- Rheumatic heart disease can lead to circulatory insufficiency and disrupt the body's natural blood clotting rhythms.
- Understanding the daily patterns of blood coagulation is crucial for managing heart disease complications.
Purpose of the Study:
- To investigate the effects of chronotherapy on blood coagulation in patients with rheumatic heart disease.
- To assess the efficacy of heparin and curantyl in correcting hemostasis disorders associated with heart failure.
Main Methods:
- Studied daily blood coagulation profiles in 20 healthy individuals and 92 patients with rheumatic heart disease (stages I-III).
- Compared traditional therapy (antirheumatics, diuretics, cardiac glycosides) with and without added chronotherapy (heparin, curantyl).
Main Results:
- Patients with decompensated heart disease showed disordered time organization of hemostasis.
- Chronotherapy with heparin and curantyl, in addition to standard treatment, effectively corrected these hemostasis disorders.
Conclusions:
- Disordered hemostasis timing is a feature of decompensated heart disease.
- Chronotherapy using heparin and curantyl offers a viable strategy to restore normal blood coagulation patterns in these patients.
Abstract:
Daily profiles of blood coagulation were studied in 20 normal subjects and 92 patients with rheumatic heart disease with stages I-III circulatory insufficiency before and after traditional therapy and chronotherapy with heparin and curantyl added to traditional therapy with antirheumatic agents, diuretics, and cardiac glycosides. Time organization of the hemostasis was disordered in patients with decompensated heart disease, but it is possible to correct it by chronotherapy with heparin and curantyl.