[A structure based pharmaceutical database for drug interactions]

Area of Science:

• Pharmaceutical Science
• Database Development
• Medicinal Chemistry

Context:

• Drug interactions pose a significant challenge in clinical practice and drug development.
• Existing drug information systems may lack comprehensive structural and interaction data.
• The need for integrated pharmaceutical data management is critical for safety and efficacy.

Purpose:

• To develop a structure-based pharmaceutical database for managing drug interaction information.
• To integrate diverse data points including chemical structures, drug codes, and adverse effects.
• To leverage existing relational database technology for pharmaceutical data organization.

Summary:

• A novel structure-based pharmaceutical database has been developed using ISIS/Desktop and Microsoft Access.
• The database incorporates Japanese accepted drug names, molecular formulas, weights, CAS numbers, and structural formulas.
• It also includes therapeutic category codes, Japan ethical drug codes, side effects, and drug interaction data.

Impact:

• Facilitates efficient retrieval and analysis of drug interaction data.
• Supports pharmaceutical research and development by providing a centralized information resource.
• Enhances drug safety monitoring and clinical decision-making through accessible interaction profiles.