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Association between Helicobacter pylori infection and serum pepsinogen concentrations in gastroduodenal disease
K Matsumoto1, N Konishi, M Ohshima
1Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan.
Aim:
To investigate the association between Helicobacter pylori infection and serum pepsinogen (PG) 1 and 2 concentrations in various gastroduodenal diseases.
Methods:
Serum PG1 and 2 concentrations and antibodies to H pylori were measured by enzyme linked immunosorbent assay (ELISA); gastric mucosal pH was assessed and urease activity in biopsy tissue was determined. A comparison of the ELISA and urease test results permitted division of the cases into positive, false positive, false negative and negative categories for control, gastritis, and ulcer groups.
Results:
The gastric mucosal pH and serum PG2 in cases positive for H pylori were significantly increased in ulcer and gastritis cases compared with H pylori negative cases. Similar tendencies were observed for the false positive and false negative categories.
Conclusions:
A positive ELISA reaction for antibodies and an increased serum PG2 concentration are reliable indicators of H pylori infection.