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Hydroxyurea dermopathy: a unique lichenoid eruption complicating long-term therapy with hydroxyurea
M S Daoud1, L E Gibson, M R Pittelkow
1Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Journal of the American Academy of Dermatology
|February 1, 1997
Summary
Long-term hydroxyurea therapy can cause a distinct skin condition called hydroxyurea dermopathy. Discontinuing the medication is necessary for improvement and healing of these skin lesions.
Area of Science:
- Dermatology
- Oncology
- Pharmacology
Background:
- Hydroxyurea is a commonly used antitumor agent.
- It is generally considered well-tolerated in patients.
Observation:
- A distinct eruption was observed in patients undergoing long-term hydroxyurea treatment.
- The study describes the clinical and histologic features of this condition.
Findings:
- Six patients (3 male, 3 female, average age 61) with hydroxyurea dermopathy were analyzed.
- Common clinical findings included lichenoid papules, telangiectasia, and poikilodermatous lesions on dorsal hands and digits.
- Histologic examination revealed interface dermatitis, epidermal atrophy, and Civatte bodies. Immunopathology showed cytoid staining.
- Four patients improved after discontinuing hydroxyurea therapy.
Implications:
- Hydroxyurea dermopathy is a characterized cutaneous reaction to long-term hydroxyurea use.
- Discontinuation of hydroxyurea is essential for managing and improving the condition.
- This highlights the importance of monitoring for dermatologic side effects in patients on long-term hydroxyurea.