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Gray-scale second harmonic imaging of the liver with galactose-based microbubbles
1Department of Gastroenterology and Hepatology, Kyoto University, School of Medicine, Japan.
Investigative Radiology
|February 1, 1997
Summary
Second harmonic imaging with SHU 508A contrast agent effectively visualizes liver perfusion in rabbits. This advanced imaging technique clearly depicts healthy tissue and necrotic tumors, showing promise for organ perfusion assessment.
Area of Science:
- Medical Imaging
- Diagnostic Ultrasound
- Contrast-Enhanced Ultrasound
Background:
- Gray-scale second harmonic imaging utilizes advanced ultrasound technology.
- SHU 508A is a galactose-based contrast agent designed for enhanced ultrasound visualization.
Purpose of the Study:
- To evaluate the efficacy of SHU 508A in gray-scale second harmonic imaging.
- To assess the agent's performance in both in vitro and in vivo settings.
Main Methods:
- Utilized a Toshiba prototype harmonic imaging system (2.5/5.0 MHz).
- Conducted phantom experiments and in vivo imaging of rabbit livers, including those with VX-2 tumors.
Main Results:
- Second harmonic imaging effectively eliminated fundamental echo components, yielding high-contrast phantom images.
- SHU 508A demonstrated clear enhancement of rabbit liver parenchyma at 0.3 mL/kg for 90 seconds.
- Necrotic VX-2 tumors were distinctly visualized as areas of negative enhancement against the enhanced liver background.
Conclusions:
- Gray-scale second harmonic imaging with SHU 508A shows significant promise for organ perfusion visualization.
- This technique offers clear differentiation between healthy tissue and pathological areas like tumors.