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Repeated monosialoganglioside administration attenuates behavioral sensitization to amphetamine
R G Bellot1, M A Vital, J Palermo-Neto
1Department of Pharmacology, Escola Paulista de Medicina/UNIFESP, Brazil.
Brain Research
|January 30, 1997
Summary
Repeated monosialoganglioside (GM1) administration reduced amphetamine-induced behavioral sensitization in mice. GM1 did not affect normal behavior but modulated adaptive changes following repeated drug exposure.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- Amphetamine-induced behavioral sensitization is a model for drug addiction.
- Gangliosides, like GM1, are involved in neuronal function and plasticity.
Purpose of the Study:
- To investigate the effect of monosialoganglioside (GM1) on amphetamine-induced behavioral sensitization.
- To determine if GM1 modulates adaptive changes in response to repeated amphetamine exposure.
Main Methods:
- Mice were treated daily with GM1 (30 mg/kg) for 7 days.
- Amphetamine (3.0 mg/kg) was administered daily for 7 days, 30 minutes after GM1.
- Locomotion frequency in an open-field test was measured as a behavioral parameter.
- Acute GM1 administration before acute amphetamine was also tested.
Main Results:
- Repeated GM1 administration did not alter baseline mouse locomotion.
- Repeated GM1 administration significantly decreased amphetamine-induced hyperlocomotion.
- Acute GM1 administration did not affect the hyperlocomotion induced by acute amphetamine exposure.
Conclusions:
- Monosialoganglioside (GM1) administration can attenuate the development of amphetamine-induced behavioral sensitization.
- These findings suggest that GM1 may influence synaptic plasticity, thereby modulating drug-induced adaptive changes.