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Updated: Aug 12, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Published on: June 6, 2017
[The synchronization of cells in culture by macromolecular complexes of platinum]
Abstract:
Divalent platinum compounds: cis-dichlorodiammineplatinum (II) (DDP) and its new macromolecular complexes poly (hexacis[chloroammineaquaplatinum(II)])-micro- deoxyribonucleats (MCP) have been used for the first time as the cell culture synchronization inductors. It is established that when monolayer cell cultures are incubated in presence of the above compounds, the conditions are created under which cell cycle is blocked at the S-phase and more then 80% of cells are accumulated in the Gl-phase. MCP compound is preferable in this case.
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