Related Experiment Video

Updated: Sep 11, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

[Pathogenesis and intensive care of infants with toxic-dystrophic syndrome]

V L Aĭzenberg, N V Vorotyntseva, V F Bogachev

    Anesteziologiia I Reanimatologiia
    |November 1, 1996
    PubMed

    Insights

    A new intensive care protocol significantly reduced mortality in children with toxic-dystrophic syndrome and enteric infection. The protocol addresses dehydration, nutrient deficiency, and impaired digestion, improving outcomes for critically ill children.

    Area of Science:

    • Pediatrics
    • Gastroenterology
    • Infectious Diseases

    Background:

    • Toxic-dystrophic syndrome in children presents with severe complications.
    • Acute enteric infections trigger significant pathological disorders.

    Purpose of the Study:

    • To investigate the pathogenetically significant disorders in children with toxic-dystrophic syndrome and acute enteric infection.
    • To evaluate the efficacy of a newly developed three-staged intensive care protocol.

    Main Methods:

    • Examined 82 children with toxic-dystrophic syndrome and acute enteric infection.
    • Identified disorders including dehydration, electrolyte imbalance, anemia, and malnutrition.
    • Implemented a novel three-staged intensive care protocol focusing on homeostasis, nutrition, and digestive repair.

    Main Results:

    • Key findings included salt-deficient dehydration, hypokalemia, anemia, hypoproteinemia, metabolic acidosis, and protein-energy malnutrition.
    • Impaired digestion and reduced intestinal absorption were primary causes of malnutrition.
    • The new protocol reduced mortality from 13.4% to 4.8%.

    Conclusions:

    • The developed intensive care protocol effectively manages critical disorders in pediatric toxic-dystrophic syndrome.
    • Correction of homeostasis, nutritional support, and digestive repair are crucial for reducing mortality.
    • This protocol offers a significant advancement in treating this severe pediatric condition.

    More Related Videos

    A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis05:39

    A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

    Published on: November 30, 2021

    Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

    Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

    Published on: October 31, 2025

    Related Concept Videos

    Teratogenicity01:07

    Teratogenicity

    The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
    Immunodeficiency Diseases01:25

    Immunodeficiency Diseases

    Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
    There are three main causes of immunodeficiency disorders...
    Botulism01:22

    Botulism

    Botulism is a life-threatening neuroparalytic condition caused by botulinum neurotoxin, which is produced by the bacterium Clostridium botulinum, a Gram-positive, spore-forming, obligate anaerobe.In adults, the toxin enters the body in different ways: in foodborne botulism, the preformed toxin is absorbed in the intestine. In wound botulism, spores grow in injured tissue and release the toxin into the blood. Infant botulism differs mechanistically from adult forms. In infants, botulism commonly...
    Diphtheria01:28

    Diphtheria

    Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...