Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

125I-galanin binding sites in Alzheimer's disease: increases in hippocampal subfields and a decrease in the caudate

R Rodríguez-Puertas1, S Nilsson, J Pascual

  • 1Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.

Journal of Neurochemistry
|March 1, 1997
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A journey to ITACA: Ion Tracking with Ammonium Cations Apparatus.

The European physical journal. C, Particles and fields·2026
Same author

Barium ion sensing with IPG K<sup>+</sup> molecular probes.

The Analyst·2025
Same author

Automated early detection of drops in commercial egg production using neural networks.

British poultry science·2017
Same author

Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation: comparison with NICE guidelines and ACOG recommendations.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2017
Same author

Parallel Computing for Brain Simulation.

Current topics in medicinal chemistry·2016
Same author

The absence of 5-HT<sub>4</sub> receptors modulates depression- and anxiety-like responses and influences the response of fluoxetine in olfactory bulbectomised mice: Adaptive changes in hippocampal neuroplasticity markers and 5-HT<sub>1A</sub> autoreceptor.

Neuropharmacology·2016

Galanin binding sites in Alzheimer's disease brains show changes, particularly in the hippocampus and caudate nucleus. These alterations in galanin systems suggest a potential role in senile dementia of the Alzheimer type (SDAT).

Area of Science:

  • Neuroscience
  • Neuropathology

Background:

  • Senile dementia of the Alzheimer type (SDAT) is a neurodegenerative disorder with complex pathological mechanisms.
  • Galanin, a neuropeptide, is implicated in various brain functions, but its role in SDAT is not fully understood.

Purpose of the Study:

  • To investigate the distribution and density of galanin binding sites in the brains of patients with SDAT compared to age-matched controls.
  • To determine if specific brain regions exhibit altered galanin binding in SDAT.

Main Methods:

  • Autoradiography was employed using iodinated human galanin to quantify galanin binding sites.
  • Brain tissue from eight SDAT patients and nine control cases was analyzed, focusing on cortical, hippocampal, and brainstem areas.

Main Results:

Related Experiment Videos

  • The highest density of galanin binding sites was observed in the substantia nigra, followed by the hippocampus and cortical regions.
  • SDAT cases showed a significant increase in galanin binding sites in some hippocampal areas and a decrease in the caudate nucleus.
  • No significant changes in galanin binding were detected in the frontal and entorhinal cortices of SDAT patients.

Conclusions:

  • The study indicates alterations in central galanin systems in patients with SDAT.
  • Changes in galanin binding sites, particularly in the hippocampus and caudate nucleus, suggest a potential derangement of galanin neurotransmission in Alzheimer's disease.