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Detection and characterization of human papillomavirus type 45 DNA in the cervical carcinoma cell line MS751
J Geisbill1, U Osmers, M Dürst
1Angewandte Tumorvirologie, Deutches Krebsforschungszentrum, Heidelberg, Germany.
The Journal of General Virology
|March 1, 1997
Abstract:
The cervical carcinoma-derived cell line MS751 was examined for human papillomavirus (HPV) DNA and RNA. A genomic fragment containing both viral and cellular sequences was cloned. Sequence analysis showed that MS751 cells contain a partially deleted HPV-45 genome integrated at a single chromosomal site. HPV sequences from the E6-E7 region are expressed as poly(A)+ RNA.