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Related Experiment Videos

Pain-evoked blink reflex

J Ellrich1, B Bromm, H C Hopf

  • 1Institute of Physiology, University Hospital Eppendorf, Hamburg, Germany.

Muscle & Nerve
|March 1, 1997
PubMed
Summary
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Painful laser stimuli selectively activate nociceptors, evoking a blink reflex (BR) similar to electrically evoked responses. This suggests nociceptive afferents contribute to the R2 component of the BR.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Pain Research

Background:

  • The blink reflex (BR) has distinct components: ipsilateral R1 and bilateral R2/R3.
  • The afferent pathway for the R2 component (tactile vs. nociceptive) remains debated.

Purpose of the Study:

  • To investigate the role of nociceptive afferents in the electrically evoked blink reflex (BR).
  • To test the hypothesis that nociceptors contribute to the R2 component of the BR.

Main Methods:

  • Selective activation of supraorbital nerve nociceptors using infrared laser stimuli in 10 subjects.
  • Comparison of laser-evoked blink reflex (LR2) with electrically evoked BR components (R1, R2, R3).

Main Results:

  • Painful laser stimuli evoked a bilateral, early polyphasic BR response (LR2) at 71 ms.

Related Experiment Videos

  • Stimulation of infraorbital and mental nerve dermatomes yielded similar results.
  • Onset latencies of laser-evoked responses align with electrically evoked R2 and R3 components.

    • Conclusions:

    • Nociceptive afferent activation by laser stimuli elicits a blink reflex response comparable to electrically evoked R2 and R3.
    • Findings support the involvement of nociceptive pathways in generating the R2 component of the blink reflex.
    • Potential mechanisms include activation of shared nociceptive fibers or convergence onto multireceptive neurons.