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Adrenomedullin: a new peptide involved in cardiorenal homeostasis?
R M Edwards1, W Trizna, N Aiyar
1Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939, USA.
Experimental Nephrology
|January 1, 1997
Abstract:
Adrenomedullin (ADM) was originally discovered in human pheochromocytoma but is now known to be widely distributed in various organs including the kidney. ADM is a potent hypotensive peptide that increases renal blood flow and causes natriuresis and diuresis. While ADM may act in a paracrine manner, circulating levels are increased in hypertension, chronic renal failure and congestive heart failure. Current evidence suggests that ADM may play an important role in cardiorenal homeostasis.