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Malignant hyperthermia induced by general anesthesia for bone marrow harvesting
N Hosoya1, K Miyagawa, T Mimura
1Third Department of Internal Medicine, University of Tokyo, Japan.
Bone Marrow Transplantation
|March 1, 1997
Summary
Bone marrow donation anesthesia can trigger rare but serious complications like rhabdomyolysis and acute kidney injury. Prompt treatment with dantrolene and supportive care led to a full recovery, highlighting the need for vigilant monitoring during marrow harvesting.
Area of Science:
- Anesthesiology
- Nephrology
- Hematology
Background:
- Bone marrow harvesting is a critical procedure for patients requiring stem cell transplantation.
- General anesthesia is commonly employed for bone marrow harvesting, carrying inherent risks.
- Rare but severe complications can arise during or after anesthesia for this procedure.
Observation:
- A bone marrow donor developed rhabdomyolysis, acute renal failure, and pulmonary edema post-anesthesia.
- Malignant hyperthermia (MH) was suspected as a potential cause for the severe adverse events.
- The patient underwent treatment with dantrolene, fluid resuscitation, and continuous hemodiafiltration.
Findings:
- The donor experienced a full recovery from the rhabdomyolysis, acute renal failure, and pulmonary edema.
- The treatment regimen, including dantrolene and supportive care, was effective in managing the complications.
- This case underscores the potential for life-threatening complications during bone marrow harvesting.
Implications:
- Malignant hyperthermia, though rare, is a critical consideration in anesthesia for bone marrow donors.
- Close patient monitoring and prompt intervention are essential to prevent severe outcomes.
- Anesthesia risks in bone marrow donation necessitate comprehensive risk-benefit assessments and preparedness for adverse events.