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Related Experiment Videos

Experimental toxoplasmosis in calves

J K Beverley, L Henry, D Hunter

    Research in Veterinary Science
    |July 1, 1977
    PubMed
    Summary
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    Calves infected with Toxoplasma gondii show a quick immune response, eliminating the parasite rapidly. Tissue cysts were not found, indicating limited long-term infection risk in cattle.

    Area of Science:

    • Veterinary Parasitology
    • Immunology
    • Food Safety

    Background:

    • Toxoplasma gondii is a widespread protozoan parasite.
    • Cattle can act as a food source for humans, posing potential transmission risks.
    • Understanding parasite dynamics in livestock is crucial for public health.

    Purpose of the Study:

    • To investigate the host-parasite interaction in calves experimentally infected with Toxoplasma gondii.
    • To determine the duration of parasite shedding and the development of tissue cysts in cattle.
    • To assess the immunological response of calves to Toxoplasma gondii infection.

    Main Methods:

    • Nine calves were inoculated with tissue cysts of a low virulence Toxoplasma gondii strain.
    • Animals were necropsied at intervals up to 10 weeks post-infection.

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  • Immunological markers (circulating antibodies, lymph node changes) and parasite presence were assessed.

    • Main Results:

    • A prompt immunological response, including circulating antibodies and lymph node reactions, was observed.
    • Toxoplasma gondii was recoverable from lymph nodes only within the first four weeks.
    • No tissue cysts were detected, and only minimal inflammatory lesions were present.

    Conclusions:

    • Calves mount a rapid and effective immune response following Toxoplasma gondii infection.
    • The parasite is quickly eliminated, with no evidence of tissue cyst formation in this model.
    • These findings suggest a low risk of persistent Toxoplasma gondii infection and cyst development in cattle.