Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Centrosome-microtubule nucleation

G Pereira1, E Schiebel

  • 1Max-Planck Institut für Biochemie, Genzentrum, Martinsried, Germany.

Journal of Cell Science
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fatty acid signatures of duck breast meat from three varieties.

Poultry science·2026
Same author

Nek1 defines a branch of centriolar microtubule length control parallel to CP110-Cep97.

Nature communications·2026
Same author

Efficacy of binders on sequestering per- and polyfluoroalkyl substances under in vitro ruminal conditions.

Journal of dairy science·2025
Same author

Determinants of short interpregnancy intervals in high-income countries: a systematic review.

Sexual and reproductive health matters·2025
Same author

First Constraint on Atmospheric Millicharged Particles with the LUX-ZEPLIN Experiment.

Physical review letters·2025
Same author

New Constraints on Cosmic Ray-Boosted Dark Matter from the LUX-ZEPLIN Experiment.

Physical review letters·2025

Microtubule formation relies on gamma-tubulin complexes at centrosomes. This review explores models of gamma-tubulin

Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Microtubule assembly is initiated at specific nucleation sites, primarily the centrosome.
  • These sites involve gamma-tubulin and associated proteins forming a gamma-tubulin ring complex.
  • The precise mechanisms of gamma-tubulin complex function in microtubule nucleation are under investigation.

Purpose of the Study:

  • To review and discuss proposed models for gamma-tubulin complex involvement in microtubule assembly.
  • To highlight current understanding and remaining questions regarding microtubule nucleation sites.

Main Methods:

  • Literature review of recent models and research on gamma-tubulin complexes.
  • Analysis of findings from Xenopus egg extracts and yeast Saccharomyces cerevisiae suppressor screens.

Related Experiment Videos

Main Results:

  • Two distinct models for gamma-tubulin complex function in tubulin assembly are presented.
  • The composition and structure of microtubule nucleation sites are becoming clearer.

Conclusions:

  • The exact roles of gamma-tubulin and associated proteins in microtubule nucleation require further elucidation.
  • Mechanisms of cell-cycle dependent regulation and potential disassembly of nucleation sites remain unknown, despite observed microtubule dynamics in mitotic cells.