Related Experiment Video
Updated: Aug 23, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
Published on: November 21, 2014
Indirect T-cell allorecognition: perspectives for peptide-based therapy in transplantation
G Benichou1, R C Tam, L R Soares
1Dept of Surgery, University of California San Francisco School of Medicine 94143-0508, USA. fcs@itsa.ucsf.edu
Abstract:
Indirect allorecognition is an important component of allotransplant rejection. Although the initial indirect alloresponse is limited to a few dominant determinants on donor major histocompatibility complex (MHC) molecules, subsequent spreading to additional determinants on recipient and donor antigens is common. Gilles Benichou and colleagues discuss the mechanisms by which immunodominance is acquired or disrupted in indirect alloresponses, and examine the implications for the design of peptide-based selective immunotherapy in transplantation.
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