The effect of vincristine on haemoglobin synthesis

Vincristine in a concentration of 0.5 and 4 X 10--(5) M causes a decrease of 16% and 73% respectively, in the synthesis of globin by peripheral blood reticulocytes. At the higher drug concentration alpha/beta ratio is significantly lower than the normal ratio of unity and is 0.83 +/- 0.09. These effects of vincristine are probably related to the ability of the vinca alkaloids to bind to ribosomes and their subunits.