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Genetics of migraine

J Haan1, G M Terwindt, M D Ferrari

  • 1Department of Neurology, Leiden University Hospital, The Netherlands.

Neurologic Clinics
|February 1, 1997
PubMed
Summary

Migraine likely has a genetic basis, with research pointing to hereditary susceptibility. Familial hemiplegic migraine is linked to chromosome 19p, which may also play a role in common migraine types.

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Area of Science:

  • Neurology
  • Genetics
  • Medical Research

Background:

  • Migraine is a common neurological disorder with a suspected hereditary component.
  • Family and twin studies suggest a genetic influence on migraine susceptibility.
  • The genetic underpinnings of migraine are not fully understood.

Purpose of the Study:

  • To explore the hereditary basis of migraine.
  • To identify potential chromosomal regions associated with migraine.
  • To investigate the genetic links in rare and common migraine subtypes.

Main Methods:

  • Review of existing family and twin studies on migraine inheritance.
  • Analysis of associations between migraine and hereditary diseases.
  • Examination of linkage studies for familial hemiplegic migraine.

Main Results:

  • Migraine susceptibility appears to be influenced by hereditary factors.
  • Familial hemiplegic migraine is linked to chromosome 19p and other genetic loci.
  • Chromosome 19p may be implicated in common migraine, though findings are inconsistent.

Conclusions:

  • A genetic predisposition likely contributes to migraine development.
  • Chromosome 19p is a significant candidate region for migraine research.
  • Further genetic studies are warranted to clarify the role of chromosome 19p in common migraine.

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