Seizures after orthotopic liver transplantation

Orthotopic liver transplantation is the accepted treatment for endstage liver disease. In the US alone, more than 3000 patients receive liver transplants yearly distributed through more than 100 liver transplant programmes. Neurological complications occur in up to 47% of these patients. Among them, seizures are one of the most common. They tend to occur during the first few weeks after transplantation. Generalized seizures are the most frequently encountered. Their aetiology is usually multifactorial requiring a comprehensive diagnostic and therapeutic approach. Seizures must be differentiated from a variety of behavioural and movement disorders. In this review article, the frequency and time of occurrence of seizures, their types and aetiology, diagnostic approaches and treatment are discussed.