Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-volume nonionic dimeric contrast medium: first experiences during complex coronary interventions

D Baumgart1, M Haude, G George

  • 1Department of Cardiology, Center of Internal Medicine, University of Essen, Germany.

Catheterization and Cardiovascular Diagnosis
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mean platelet volume: comparison of three analysers towards standardization of platelet morphological phenotype.

International journal of laboratory hematology·2012
Same author

[Arterial stiffness and pulse wave analysis].

Deutsche medizinische Wochenschrift (1946)·2010
Same author

Nephrotoxicity of iso-osmolar versus low-osmolar contrast media is equal in low risk patients.

Clinical nephrology·2006
Same author

Post-interventional homocysteine levels: failure as a predictive biomarker of in-stent restenosis.

International journal of cardiology·2006
Same author

Relevance of the NOS3 T-786C and G894T variants for cholinergic and adrenergic coronary vasomotor responses in man.

Basic research in cardiology·2005
Same author

Insulin sensitivity and coronary vasoreactivity: insulin sensitivity relates to adenosine-stimulated coronary flow response in human subjects.

Clinical endocrinology·2004
Same journal

Balloon mitral valvuloplasty: double vs single transseptal puncture.

Catheterization and cardiovascular diagnosis·1998
Same journal

Early experience with the Bard XT stent.

Catheterization and cardiovascular diagnosis·1998
Same journal

Bifurcation stenting: the task ahead.

Catheterization and cardiovascular diagnosis·1998
Same journal

Protection of side-branches in coronary lesions with a new stent design.

Catheterization and cardiovascular diagnosis·1998
Same journal

Subselective opacification of a left internal mammary artery graft in a tortuous subclavian artery: use of angioplasty technique and a Tracker catheter.

Catheterization and cardiovascular diagnosis·1998
Same journal

Imaging factors and image optimization.

Catheterization and cardiovascular diagnosis·1998
See all related articles

High-volume nonionic dimeric contrast media like iodixanol show minimal renal and hemodynamic side effects in complex coronary interventions for patients without prior kidney issues. This study suggests good tolerability and effectiveness for cardioangiography.

Area of Science:

  • Cardiology
  • Radiology
  • Nephrology

Background:

  • Interventional cardiology procedures are increasing, often requiring large volumes of contrast media.
  • Newer nonionic, dimeric contrast agents offer improved tolerability and reduced side effects.
  • Complex coronary interventions necessitate high contrast volumes, raising concerns about renal and hemodynamic impacts.

Purpose of the Study:

  • To evaluate the renal and hemodynamic effects of high-volume nonionic, dimeric contrast medium (iodixanol) during complex coronary interventions.
  • To assess the safety and tolerability of iodixanol in patients undergoing routine hospital-based cardioangiography.

Main Methods:

  • Retrospective analysis of 25 patients undergoing complex coronary interventions with >500 ml iodixanol.
  • Monitoring serum creatinine levels pre- and post-procedure (2 days) to assess renal function.

Related Experiment Videos

  • Evaluating heart rate and left ventricular pressures before and after left ventricular angiography for hemodynamic effects.

    • Main Results:

    • Mean serum creatinine increased significantly from 0.9 to 1.1 mg/dl (P < 0.05) 2 days post-intervention.
    • No significant changes were observed in heart rate, left ventricular systolic pressure, or end-diastolic pressure.
    • No major adverse events were reported during the 2-day follow-up period.

    Conclusions:

    • High-volume iodixanol administration in patients without pre-existing renal insufficiency is associated with minor renal function impairment and minimal hemodynamic side effects.
    • Iodixanol 320 mg I/ml is well-tolerated and effective for cardioangiography in this patient group.
    • Prospective studies are recommended to further investigate high-volume contrast media effects in both healthy and high-risk patients.