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Related Experiment Videos

NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex

A C Flint1, U S Maisch, J H Weishaupt

  • 1Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 1, 1997
PubMed
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The NR2A subunit of NMDA receptors speeds up their function during development. This finding explains how NMDA receptor properties change, impacting learning and memory.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • NMDA receptors are crucial for learning, memory, and neural development.
  • NMDA receptor-mediated EPSCs shorten after peak cortical plasticity.
  • Changes in NMDA receptor subunit gene expression likely underlie altered receptor properties.

Purpose of the Study:

  • To investigate the expression of NR2 subunits (NR2A-D) in individual neurons.
  • To determine which NR2 subunits regulate NMDA receptor properties during development in vivo.

Main Methods:

  • Analysis of NR2 subunit gene expression in single neurons of postnatal neocortex.
  • Characterization of NMDA receptor properties in relation to NR2 subunit expression.

Main Results:

Related Experiment Videos

  • Neurons expressing NR2A subunit mRNA exhibited faster NMDA receptor-mediated EPSCs (NMDAR EPSCs).
  • NR2A expression, even at low levels, was sufficient to alter NMDAR EPSC time course.
  • The proportion of NR2A-expressing cells with fast NMDAR EPSCs increased developmentally.

Conclusions:

  • NR2A subunit expression is a key molecular mechanism for the developmental decrease in NMDAR EPSC duration.
  • This developmental shift in NR2A expression provides a basis for altered NMDA receptor function in the mature brain.