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Neonatal thyroid function is unaffected by single treatment with different preparations of povidone-iodine on a wide
1Department of Pediatrics, Children's Medical Center, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Insights
Single Povidone-iodine (PV-I) skin disinfection in newborns did not affect thyroid function. Serial measurements of thyroxine (T4) and thyroid-stimulating hormone (TSH) showed no significant changes in treated or control infants.
Area of Science:
- Neonatal Medicine
- Endocrinology
- Dermatology
Background:
- Povidone-iodine (PV-I) is a widely used antiseptic in healthcare settings.
- Previous research indicates that iodine can be absorbed through the skin.
- The impact of PV-I on neonatal thyroid function requires specific investigation due to potential absorption.
Purpose of the Study:
- To evaluate the effect of a single application of different Povidone-iodine preparations on thyroid hormone levels in full-term newborns.
- To assess the safety of topical PV-I antiseptics regarding neonatal thyroid function.
Main Methods:
- A study involving 48 full-term neonates was conducted.
- Participants were divided into groups receiving tincture PV-I, aqueous PV-I, tincture PV-I with alcohol, or no treatment (control).
- Serial measurements of serum thyroxine (T4) and thyroid-stimulating hormone (TSH) were performed post-treatment.
Main Results:
- No statistically significant alterations in serum T4 or TSH levels were observed in any of the treatment groups compared to the control.
- Thyroid function remained stable across all neonates, irrespective of the PV-I preparation used.
Conclusions:
- A single topical application of Povidone-iodine, in either aqueous or tincture form, does not significantly impact the thyroid function of full-term neonates.
- The findings suggest that PV-I is safe for single-dose neonatal skin disinfection, even over a wide surface area.
Abstract:
Povidone-iodine (PV-I) are commonly used for disinfection in hospitals. Previous investigators had proved that iodine can be absorbed from the skin. In an attempt to determine the effect of single treatment of various PV-I preparations on thyroid function in fullterm newborns, serial measurements of serum thyroxine (T4) and Thyroid stimulating hormone (TSH) were done in 48 neonates treated with one dose antiseptics (tincture PV-I, aqueous PV-I, tincture PV-I followed with 75% alcohol and no treatment in control group). The results revealed no significant change of thyroid function in any study group. In conclusion, PV-I with different preparations, aqueous or tincture, did not significantly influence neonatal thyroid function if they were used to a fullterm neonate only once and even to a wide skin surface.