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Related Experiment Videos

Sensitization to cockroach in Italy: a multicentric study

G G Riario-Sforza1, F Della Torre, L Antonicelli

  • 1Allergy Unit, Buzzi Hospital, Milan, Italy.

Allergy and Asthma Proceedings
|January 1, 1997
PubMed
Summary
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Cockroach sensitization affects 13% of patients with rhinitis and asthma. Cross-reactivity with dust mite allergy is common, requiring further clinical evaluation for cockroach extract in allergy testing.

Area of Science:

  • Allergy and Immunology
  • Respiratory Medicine
  • Environmental Health

Background:

  • Sensitization to allergens is a major cause of respiratory diseases like rhinitis and asthma.
  • Cockroach (CR) allergen exposure is prevalent in indoor environments and linked to allergic respiratory conditions.
  • Standard allergy testing panels may not always include cockroach as a routine allergen.

Purpose of the Study:

  • To determine the prevalence of sensitization to cockroach allergen in patients with rhinitis and asthma in Italy.
  • To investigate the potential cross-reactivity between cockroach and Dermatophagoides pteronyssinus (Dp) allergens.
  • To evaluate the suitability of cockroach extract for inclusion in standard skin prick test (SPT) panels.

Main Methods:

  • Skin prick tests (SPT) were performed on 1299 patients with rhinitis/asthma using cockroach extract.

Related Experiment Videos

  • Patients with positive cockroach SPT underwent SPT with Dermatophagoides pteronyssinus extract.
  • Radioallergosorbent test (RAST) inhibition and isoelectric focusing (IEF) were used to assess cross-reactivity and allergen composition.

    • Main Results:

    • A total of 170 patients (13%) showed positive SPT to cockroach extract.
    • Of those with positive cockroach SPT, 133 (78.2%) were also positive for Dermatophagoides pteronyssinus.
    • RAST inhibition and IEF confirmed cross-reactivity between cockroach and Dermatophagoides pteronyssinus allergens.

    Conclusions:

    • The 13% prevalence of cockroach sensitization suggests its potential utility in standard allergy testing for respiratory conditions.
    • Significant cross-reactivity between cockroach and Dermatophagoides pteronyssinus allergens necessitates careful consideration of clinical relevance.
    • Further research is needed to clarify the specific clinical impact of cockroach sensitization in the studied population.