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Assisted implantation: direct intraendometrial embryo transfer
J Itskovitz-Eldor1, S Filmar, D Manor
1Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel.
Gynecologic and Obstetric Investigation
|January 1, 1997
Summary
Direct intraendometrial transfer (DIET) of human embryos resulted in low pregnancy rates. The endometrial stroma may not be optimal for early embryo development, potentially due to CO2 insufflation effects.
Area of Science:
- Reproductive Medicine
- Embryology
- Gynecology
Background:
- Direct intraendometrial transfer (DIET) is a novel technique for human embryo implantation.
- The viability of embryos transferred directly into the endometrial stroma requires investigation.
Purpose of the Study:
- To evaluate the efficacy of DIET for achieving viable pregnancies.
- To assess the suitability of the endometrial stroma as an implantation environment for early-stage embryos.
Main Methods:
- In vitro fertilization followed by direct intraendometrial transfer of 44 two-day human embryos into 14 women.
- Embryo injection was performed under direct visualization using a CO2-pulsed flexible hysteroscope.
Main Results:
- Two clinical pregnancies (14.3% per cycle) and two chemical pregnancies were achieved.
- One pregnancy resulted in a healthy live birth; another was terminated due to monosomy X.
- The overall implantation rate was low, suggesting suboptimal conditions.
Conclusions:
- Pregnancy is achievable via DIET in humans, but the current low implantation rate indicates limitations.
- The endometrial stroma may not be an ideal environment for early embryonic development, possibly affected by CO2 insufflation.
- DIET may be considered for specific cases requiring precise implantation site determination.